Remove your pork loin from the Ziploc and keep as much of the marinade on it as possible when placing it on your smoker. Insert a probe thermometer about 2-3 inches into the center of the larger side of the pork loin. This will ensure doneness throughout the entire piece of meat.
Smoke at 225 degrees Fahrenheit for 2-3 hours (depending on ambient temperature) or until your pork loin reaches an internal temperature of 145-150 F for medium rare, 150-155 F for medium or 155-160 F for medium-well. Let your pork rest for 5-10 minutes to allow the juices to incorporate back into the meat before slicing and enjoying.